Endocrine Abstracts

Background: Obesity-related, isolated hypogonadotropic hypogonadism (IHH) occurs in more then 40% of morbidly obese men.Hypothesis: IHH and prolonged persistence of low testosterone levels after bariatric procedures may reduce the beneficial effects of surgery.Objective: To evaluate the impact of IHH on the results of bariatric surgery.Patients and methods: observational study with measurement of gonadal horm...

Androgen excess is a key feature of the polycystic ovary syndrome; however the molecular mechanisms underlying its pathogenesis largely remain elusive. Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in the human circulation but only unconjugated dehydroepiandrosterone (DHEA) can be converted to active androgens. Conversely, conversion of DHEA to its sulfate ester DHEAS by DHEA sulfotransferase, SULT2A1, diminishes the DHEA pool available for androgen gener...